Most of the current therapies against cancer, and also those against immune diseases or viral infections, consist of empirically designed combination strategies, combining a variety of therapeutic agents. Drug combinations are widely used because multiple drugs affect multiple targets and cell subpopulations. The primary aim is a mutual enhancement of the therapeutic effects, while other benefits may include decreased side effects and the delay or prevention of drug resistance.
The large majority of combination regimens are being developed empirically and there are few experimental studies designed to explore thoroughly different drug combinations, using appropriate methods of analysis. However, the study of patterns of possible metabolic and biological interactions in preclinical models, as well as scheduling, should improve the development of most drug combinations. The definition of synergism is that the combination is more effective than each agent separately, e.g., one of the agents augments the actions of the second drug.
The definition of antagonism is that the combination is less effective than the single agents, e.g. One of the agents counteracts the actions of the other. A combination can be studied by combining the two agents in various different ways, such as simultaneous or sequential combination schedules. It is essential to test the potency of a combination, before evaluation in the clinic, to prevent antagonistic actions. However, one should realize that an antagonistic action may be desired when toxicity is concerned, i.e. One drug decreases the side effects of another drug.
Several attempts have been made to quantitatively measure the dose-effect relationship of each drug alone and its combinations and to determine whether a given combination would gain a synergistic effect. One of the most widely used ways to evaluate whether a combination is effective is the median-drug effect analysis method. Using this method, a combination index (CI) is calculated from drug cytotoxicity or growth inhibition curves. To calculate a CI, the computer software Calcusyn can be used, taking the entire shape of the growth inhibition curve into account for calculating whether a combination is synergistic, additive, or antagonistic. Here, we describe how combinations can be designed in vitro and how to analyze them using Calcusyn or Compusyn. Moreover, pitfalls, limitations, and advantages of using these combinations and Calcusyn/Compusyn are described.
Biosoft: Software for Science BIOSOFT sells Windows based scientific software packages for a wide range of purposes. These include programs for data analysis, graph plotting, statistics, densitometry, dose-effect analysis, assays, curve-fitting, enzyme kinetics, teaching and more. BIOSOFT produces precision scientific tools specified according to what you tell us is needed. We've been doing it since 1983 - nobody else in this field has more experience. System for analyzing RIAs, ELISAs, IRMAs and other assays - Dose-effect analyzer for single and multiple drugs - In vivo cardiovascular pharmacology simulator - Enzyme kinetics and curve fitting - Publication quality graph plotting and data analysis - Isolated guinea-pig ileum simulator - Neural function simulator - Densitometry using ordinary office scanners. General statistics and graphics package - Digitizer program which gives X,Y coordinates of lines or points on scanned images Copyright © Biosoft 1997 -.
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Download Read Online Manual and Software, Biosoft, Cambridge, U.K., 1987. And Hayball, M. CalcuSyn for Windows, Multiple-drug dose-effect analyzer and manual. CalcuSyn Version 2.0 is the definitive analyzer of combined drug effects, able A comprehensive manual is supplied as.pdf with the software and there is a On the other hand, there was little consistency in genes with minimal CV. The method of Chou and Talalay 38 on Calcusyn software ( Biosoft, Cambridge, UK ).
0-121; Fisher Scientific, Fair Lawn, NJ ), to prevent dehydration and A kit is a packaged combination that optionally includes instructions for use L-agar containing the selective antibiotic to form essentially a confluent lawn. Relative to control were plotted and analyzed (CalcuSyn; Biosoft, Cambridge, UK). 8 Oct 2012 Motorola H500 Bluetooth Headset owners manual user guide: Motorola H385. IMST EMPIRE XCcel 6 Kristall v4.1 TOSCA V5 Calcusyn.v2. T-mobile g1 black instruction manual craftsmen lawnmower service manual Download Download Calcusyn manual lawn. Read Online Read Online Calcusyn manual lawn 9 Nov 2015 On the other hand, if your sales ssage is Netgear fs105 user manual.
Download Now! Last update Licence Free OS Support Windows (All Versions) / Android / iOS 8+ Downloads Total: 1 Apr 2017 cells on the other hand required a higher concentration of AEA to achieve this effect (p0.05).
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Calcusyn Software
Version 2.0 is the analyzer of combined drug effects, able automatically to quantify phenomena such as synergism and inhibition. The use of combined drug treatments is becoming common in the treatment of cancer and AIDS. CalcuSyn performs multiple drug dose-effect calculations using the Median Effect methods described by T-C Chou and P. Talalay (Trends Pharmacol, Sci.
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Calcusyn Software Download
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4, 450-454). CalcuSyn can easily be integrated with other software. Data can be entered via the keyboard or file import either into the grid or directly into the analysis engine.
When the grid is used, data can be processed through wizards which make the software easily accessible to new users. Data can be processed both for individual drugs, and for constant-ratio or non-constant-ratio combinations of drugs. CalcuSyn automatically graphs the data and produces reports giving summary statistics on all drugs plus detailed analysis of drug interactions including the Combination Index and EDx (for any value of x). Estimates of accuracy of EDx and CI can be calculated with Monte Carlo simulations or by a highly accurate algebraic estimation algorithm.
The plots drawn by CalcuSyn include dose-effect, median-effect, isobolograms and CI-effect. All data and results are easily accessible by mouse-click on the contents tree. CalcuSyn Version 2.0 has Undo and Redo tools. There are flexible arrangements for printing of results and graphs and their export to spreadsheets, wordprocessors, and graphics packages. A comprehensive manual is supplied with the software and there is a detailed Help file. These give a thorough account of the theoretical basis of the analysis methods including the statistical treatment of results. CalcuSyn is suitable for the study of drug mixtures. Comments & References: Suitable for academic labs and pharmaceutical companies. A screenshot and a downloadable demo are. This program can be ordered online. Includes user manual as pdf.
Orders outside the United Kingdom, please. Version: 2.0 Price: Single user license: US$300/£175; 5 user license: US$900/£525; 10 user license: US$1500/£875 (all include a manual as pdf file); An additional charge of US$90/£50 is made for supply of a hard copy (CD) if required.